کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10584898 981355 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
چکیده انگلیسی
Four metabolites of okadaic acid were generated by incubation with human recombinant cytochrome P450 3A4. The structures of two of the four metabolites have been determined by MS/MS experiments and 1D and 2D NMR methods using 94 and 133 μg of each metabolite. The structure of a third metabolite was determined by oxidation to a metabolite of known structure. Like okadaic acid, the metabolites are inhibitors of protein phosphatase PP2A. Although one of the metabolites does have an α,β unsaturated carbonyl with the potential to form adducts with an active site cysteine, all of the metabolites are reversible inhibitors of PP2A.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 12, 15 June 2012, Pages 3742-3745
نویسندگان
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