Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors

A series of novel β-diketo derivatives which combined the virtues of 1,3-diketo, 1,2,3-triazole and polyhydroxylated aromatics moieties were prepared and their HIV-1 IN inhibitory activities were evaluated. The polyhydroxylated aromatic moiety plays an important role in the inhibitory of HIV integrase.