6-Nitrobenzimidazole derivatives: Potential phosphodiesterase inhibitors: Synthesis and structure-activity relationship

Synthesis of 6-nitrobenzimidazole derivatives 1-30 showed excellent phosphodiesterase inhibitory activities some of which are superior to the standard EDTA and thus are potential molecules for the development of a new class of phosphodiesterase inhibitors. A structure-activity relationship is evaluated.