Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein

A novel family of hybrid peptidomimetic Stat3 inhibitors that bind to STAT3's SH2 domain with a high affinity, disrupt STAT3:phosphopeptide complexation events and inhibit STAT3-STAT3 protein dimerization in vitro and in whole cells containing aberrant STAT3 activity.