Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

Novel fluorinated styryl benzazoles have been synthesized and evaluated in vitro as amyloid-probing agents. The compounds interact with fibrillary species with a red-shift in the excitation wavelenghts along with an increase in the fluorescence emission intensity, appearing as good candidates to design 18F-labelled amyloid radioprobes.