Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans

► Ptilomycalin A (PTA) suppresses melanization in Cryptococcus neoformans var gatti. ► PTA A also inhibits fungal laccase with an IC50 of 4.7 μM. ► Amphotericin B antifungal activity is potentiated by PTA. ► PTA may be a useful adjuvant for antifungal therapy.