کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10586396 981390 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and in vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line
چکیده انگلیسی
The present work reports the synthesis of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones and the evaluation of their cytotoxic activity against human breast cancer cell MCF-7. In addition, the effect of selected compounds on the activities of free-radical-metabolizing enzymes as well as the levels of oxidative stress parameters in MCF-7 cells was estimated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 22, 15 November 2011, Pages 6808-6817
نویسندگان
, , , , ,