Synthesis and characterization of [125I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1

A series of radio-iodinated 1-methylpiperidin-2-yl benzamide derivatives have been synthesized and evaluated in vitro and in vivo as potential SPECT probes for imaging of glycine transporter 1.