Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents

A novel set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole has been synthesized and its antiprotozoal, antibacterial and antifungal activities evaluated. Also, their physicochemical and structural properties were explored to establish qualitative property-activity relationships.