Synthesis and anticancer activity of 5′-chloromethylphosphonates of 3′-azido-3′-deoxythymidine (AZT)

A series of novel N-alkyl 5′-chloromethylphosphonates of 3′-azido-3′-deoxythymidine (AZT) were synthesized and evaluated for their cytotoxic activity in two human cancer cell lines: oral (KB) and breast (MCF-7).