Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils

New chemistries were developed and series of adenosine/boron cluster conjugates was synthesized and screened for activity as inhibitors of reactive oxygen species (ROS) production in neutrophils. The high activity and affinity of the selected compounds for adenosine receptor A2A was established. This study extends the range of innovative molecules available for testing as agents affecting inflammatory processes.