A click chemistry approach to pleuromutilin derivatives. Part 3: Extended footprinting analysis and excellent MRSA inhibition for a derivative with an adenine phenyl side chain

A series of seven pleuromutilin derivatives were studied by chemical footprinting for the binding to Escherichia coli ribosomes and for their ability to inhibit the growth of two Staphylococcus aureus strains. One compound shows an excellent effect similar to the known drug valnemulin.