Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

Herein, we describe the design, synthesis and anticancer activity of a series of AraU phosphoramidates. In addition, we report on the metabolism of these phosphoramidates by carboxypeptidase Y and molecular modelling studies investigating the possible cleavage of the P-N bond. Cell extract studies complement the modelling study.