کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588106 981445 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromomycin SA analogs from a marine-derived Streptomyces sp.
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Chromomycin SA analogs from a marine-derived Streptomyces sp.
چکیده انگلیسی
Two chromomycin SA analogs, chromomycin SA3 and chromomycin SA2, along with deacetylchromomycin A3 and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA3 and chromomycin SA2 are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 17, 1 September 2011, Pages 5183-5189
نویسندگان
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