Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

Imidazo[1,2-a]pyridine-3-amines were synthesised using the Groebke reaction and tested for anti-HIV activity. Compounds prepared from 2-chlorobenzaldehyde, and a combination of cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhibitory activity in a reverse transcriptase assay and whole cell anti-HIV infectivity assays.