18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells

Twenty-six 18β-glycyrrhetinic acid (GA) (1) derivatives 2-27 including twelve new GA derivatives 10, 11, 13-17, 21-25 were synthesized and evaluated for cytotoxicities against NTUB1cell. Compound 25 induced a mitochondrial-mediated apoptosis in NTUB1 through activation of p53, which are mainly mediated ROS generated by 25.