Synthesis of chalcone derivatives as potential anti-diabetic agents

Structure-activity relationship: chalcones derivatives with hydroxy (2b), chloro (4a), bromo (5b) and iodo (6a, 6b and 6c) substitutions at position 2 on A-ring and compounds (6e and 6g) with iodo substitution at position 3 on A-ring also showed the effect of enhance glucose uptake in 3T3-L1 adipocytes.