Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter

Four sets of enantiomeric derivatives of benzovesamicol were synthesized and their binding affinities for the VAChT determined in vitro. The high affinity of the fluorinated (5-FPOBV) and the iodinated (5-AOIBV) derivatives make them potential PET or SPECT radiotracers.