13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit

By using radiolabeled ligand derived from 13-deoxytedanolide, the ribosome was identified as the target molecule of 13-deoxytedanolide. As expected, 13-deoxytedanolide inhibited polypeptide elongation at low concentration.