Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis

The minimal peptide epitope required for binding to MHC-II molecules associated with arthritis in mice, was determined to be CII260-266. Elongation to give CII260-267 and glycosylation on Hyl 264 gave an epitope that stimulated T-cell hybridomas obtained from arthritic mice.