Synthesis and cellular studies of an octa-anionic 5,10,15,20-tetra[3,5-(nido-carboranylmethyl)phenyl]porphyrin (H2OCP) for application in BNCT

The synthesis, dark cytotoxicity, cellular uptake and intracellular localization of a high boron content octa(nido-carboranyl)porphyrin are described and compared with a known tetra(nido-carboranyl)porphyrin. The molecular structure of an octa(closo-carboranyl)porphyrin is presented.