Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series

The synthesis of series of hitherto unknown 5-alkynyl pyrimidine acyclic nucleosides and their furopyrimidine analogues is described. The in vitro antiviral activity (HIV, HSV-1) and toxicity in different cell lines are reported.