کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10591063 | 981739 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
One-pot synthesis of cinnamylideneacetophenones and their in vitro cytotoxicity in breast cancer cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: One-pot synthesis of cinnamylideneacetophenones and their in vitro cytotoxicity in breast cancer cells One-pot synthesis of cinnamylideneacetophenones and their in vitro cytotoxicity in breast cancer cells](/preview/png/10591063.png)
چکیده انگلیسی
A series of cinnamylideneacetophenones were synthesized via a modified Claisen-Schmidt condensation reaction and evaluated for cytotoxicity against breast cancer cells using the Alamar Blue⢠assay. Derivatives 17 and 18 bearing a 2-nitro group on the B ring, exhibited sub-micromolar cytotoxicity in MCF-7 cells (IC50 = 71 and 1.9 nM), respectively. Derivative 17 also displayed sub-micromolar (IC50 = 780 nM) cytotoxicity in MDA-MB-468 cells. Additionally, 17 and 18 displayed significantly less cytotoxicity than the chemotherapeutic doxorubicin in non-tumorigenic MCF-10A cells. This study provides evidence supporting the continued development of nitro-substituted cinnamylideneacetophenones as small molecules to treat breast cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 15, 1 August 2014, Pages 3381-3384
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 15, 1 August 2014, Pages 3381-3384
نویسندگان
David J. Weldon, Marilyn D. Saulsbury, Joshua Goh, Leah Rowland, Petreena Campbell, Laijia Robinson, Calvin Miller, Joshua Christian, Louisa Amis, Nia Taylor, Cassandra Dill, Willie Jr., Stanley L. Evans, Eileen Brantley,