Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

Compound 11 displayed the most potent EGFR TK inhibitory activity with IC50 of 0.06 μM, which was comparable to the positive control. Molecular docking results indicated that compound 11 was nicely bound to the EGFR kinase with three hydrogen bonds. Compound 11 also showed significant antiproliferative activity against MCF-7 with IC50 of 0.07 μM, which would be a potential anticancer agent.