کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10594505 | 981831 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Viridin analogs derived from steroidal building blocks
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Viridin analogs derived from steroidal building blocks Viridin analogs derived from steroidal building blocks](/preview/png/10594505.png)
چکیده انگلیسی
Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex natural products from abundant steroid feedstock materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast cancer line.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 22, 15 November 2012, Pages 6919-6922
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 22, 15 November 2012, Pages 6919-6922
نویسندگان
Kishore Viswanathan, Sophia N. Ononye, Harold D. Cooper, M. Kyle Hadden, Amy C. Anderson, Dennis L. Wright,