New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors

The compounds show cytotoxic activity against multidrug resistant LoVo/DX, MES-SA/DX5 and HL-60 sublines, induce the G2M phase cell cycle arrest in Jurkat cells, and inhibit topoisomerase II activity.