کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10597038 | 981955 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of low methoxyl pectin gel textures and in vitro release of rutin from calcium pectinate beads
ترجمه فارسی عنوان
تاثیر بافت ژل متکسیل پکتین و آزمایش ریتین در دانه های پکتیناسیون کلسیم
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
This study described the preparation and characterization of low methoxyl pectin (LMP) gels and beads for controlled release applications. The rheological characterization of the various formulations was proposed. Then the mechanical and morphological characterizations of beads were determined. Finally, the controlled release studies taking rutin as a model drug was evaluated. The results showed that Young's modulus values of non-amidated LMP gels decrease when adding up to 15% sorbitol. Calcium pectinate beads loaded with rutin are about 600 μm, oblong shaped with dense matrix. Beads containing sodium bicarbonate showed about 80% lower rutin encapsulation efficiency by increasing the pH of the cross-linking solution. The rutin loaded in non-amidated pectinate beads containing 15% sorbitol showed the best release efficiency and swelling behavior. Therefore, the gel texture affects the release rate of the active compounds encapsulated in calcium pectinate beads and can be used as a parameter to modulate drug release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 335-342
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 335-342
نویسندگان
Pensak Jantrawut, Ali Assifaoui, Odile Chambin,