Alginate-based composite sponge containing silver nanoparticles synthesized in situ

► Silver nanoparticles (AgNPs) were synthesized in a sodium alginate solution. ► Alginate-AgNPs composite sponge was prepared from the nanocolloid solution. ► The alginate-AgNPs composite sponge had a highly enhanced antimicrobial activity. ► The amount of proinflammatory cytokines was reduced with the composite sponge.