Design, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2

To develop novel PPARγ agonists, we synthesized several 3-{4-(2-aminoethoxy)phenyl}propanoic acid derivatives designed on the basis of the structures of rosiglitazone and 15d-PGJ2. In this series, compound 9 was found to be as potent as rosiglitazone. A binding mode analysis of 9 using computer calculations is also reported.