Cavitation effect on chitosan nanoparticle size: A possible approach to protect drugs from ultrasonic stress

► Chitosan (CH) nanoparticles were prepared by means of the ionotropic gelation method. ► We verified the influence of different ultrasonic radiations on CH nanoparticle size. ► All the ultrasonic parameters showed important influences on nanoparticle size. ► Ultrasound application only to the chitosan dispersion preserve drug loading.