Prilling for the development of multi-particulate colon drug delivery systems: Pectin vs. pectin-alginate beads

► Colon targeted dextran beads are prepared by prilling and an enteric coating. ► Optimization of process parameters may control beads properties. ► Strength of the Zn-pectinate matrix allows to reduce the thickness of the coating. ► Piroxicam loaded multi-particulate systems show a prolonged drug release in IF. ► Such platforms may be proposed for the treatment of inflammatory bowel diseases.