Proinflammatory activity of an alginate isolated from Sargassum vulgare

► The alginate from Sargassum vulgare is a promising antitumor compound with immunomodulatory activity. ► The isolated alginate from S. vulgare induced paw edema, mast cells degranulation and neutrophil migration in vivo. ► This activity depends on the activation of resident cells, being the macrophages the main cells involved.