In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation

► We used alginate dialdehyde for biological tissue fixation. ► Its cytocompatibility for biological tissue fixation was evaluated thoroughly. ► It is a study which has not been reported elsewhere. ► Both glutaraldehyde and genipin were used as experimental controls. ► The alginate dialdehyde is an excellently cytocompatible crosslinking reagent.