Acrylic acid grafted guargum-nanosilica membranes for transdermal diclofenac delivery

► Guargum based hydrophobic bionanocomposites for transdermal diclofenac delivery. ► Acrylic acid grafting in presence of nanosilica generates cage morphology. ► The cage density maximizes at 1 wt% nanosilica content. ► Corresponding bionanocomposite shows slowest drug release for high encapsulation.