Thiolated xyloglucan: Synthesis, characterization and evaluation as mucoadhesive in situ gelling agent

► Xyloglucan is a natural polysaccharide suitable for mucosal delivery. ► Thiolation of xyloglucan to enhance bioadhesive property of xyloglucan. ► Characterization of thiolated xyloglucan as mucoadhesive gelling agent. ► Thiolated xyloglucan undergoes rapid in vitro and in vivo degradation. ► Thiolated xyloglucan is found to be safe to mucosa.