Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis

► HMW-HA induced Akt and increased PPARγ in chondrosarcoma cells. ► HMW-HA reduced COX-2 and MMPs expression by suppressing MAPKs and NFκB signaling. ► Oligo-HA inhibited Akt, and reduced PPARγ in the cells. ► Oligo-HA increased COX-2 and MMPs expression via activation of p38 and NFκB.