Scleroglucan compatibility with thickeners, alcohols and polyalcohols and downstream processing implications

► Sclerotium rolfsii ATCC 201126 EPSs were compatible and synergistic with commercial hydrocolloids. ► Mixtures with polyethylene glycol (PEG) or lower alcohols induced EPSs precipitation. ► PEG-based scleroglucan downstream processing would be unsuitable. ► Purity, solubility, rheological properties and appearance were optimal for isopropanol-purified EPSs. ► Isopropanol-downstream processing was appropriate for obtaining refined-grade scleroglucan.