Optimization of extraction process of crude polysaccharides from Pomegranate peel by response surface methodology

► Extraction of crude polysaccharides from Pomegranate peel. ► Response surface methodology was used. ► Extraction time, temperature and ratio of water to the raw material were discussed. ► Model was set up to optimization extraction of Pomegranate peels polysaccharides. ► The best extraction methods were 98 °C, 1.9 h and 37 ml/g of ratio of water to material.