Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis

► Sulphated polysaccharide was extracted from brown seaweed of Sargassum plagiophyllum. ► Entire thallus having SPs and blade contains more polysaccharides than other parts. ► Q-Sepharose fast flow anion-exchange chromatography was used to purify fucoidan. ► Fucoidan involved in oxidative stress and mitochondrial damage in Wister rats. ► Fucoidan treated HCC rat liver exhibited different pathological appearances.