Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization

► Production of chitooligosaccharides with defined degrees of polymerization and acetylation. ► Chitooligosaccharides inhibit the formation of new blood vessels in a chicken chorioallantoic membrane assay. ► Chitooligosaccharides inhibit the migration of induced ECV304 cells in a “scratch wound” assay. ► Chitooligosaccharides, with DP 3-12 and FA0.3 have considerable anti-angiogenic effects.