Stimuli-responsive materials prepared from carboxymethyl chitosan and poly(γ-glutamic acid) for protein delivery

► Genipin (GP)-conjugated polymers with fluorescence properties. ► Fluorescence quenched by gluconic acid and hydrogen peroxide. ► Self-aggregated nanoparticles in response to the stimulus of gluconic acid. ► Slow release of protein from nanoparticles at hyper gluconic acid conditions.