کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10602588 | 982388 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid](/preview/png/10602588.png)
چکیده انگلیسی
Salicylic acid (SA) and gentamicin (GM) loaded nanoparticles of chitosan (CS) cross-linked with tripolyphosphate (TPP) were prepared and used to inhibit the ototoxicity of GM. The prepared nanoparticles were characterized by FT-IR spectroscopy to confirm the cross-linking reaction between CS and cross-linking agent. X-ray diffraction (XRD) was performed to reveal the crystalline nature of the drug after encapsulation. Up to 24.67 ± 2.06% of SA and 26.64 ± 3.92% of GM were loaded into the nanoparticles and the average size of nanoparticles ranged from 148 ± 8.6 to 345.0 ± 12.9 nm. The nanoparticles formed were spherical in shape with high zeta potentials (higher than +30 mV). In vitro release studies in phosphate buffer saline (pH 7.4) showed an initial burst effect and followed by a slow drug release. The drug release followed Weibull equation and a non-Fickian transport. The amounts of SA and GM released from the nanoparticles met the dosage ratio requirement for inhibiting ototoxicity of GM by SA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 85, Issue 4, 1 July 2011, Pages 803-808
Journal: Carbohydrate Polymers - Volume 85, Issue 4, 1 July 2011, Pages 803-808
نویسندگان
Jingou Ji, Shilei Hao, Danjun Wu, Rui Huang, Yi Xu,