Antioxidant activity and potential hepatoprotective effect of polysaccharides from Cyclina sinensis

► There were α-type glycosidic linkages in CSPS-1 and CSPS-2. ► Average molecular weights of CSPS-1, CSPS-2 and CSPS-3 were 69, 81 and 101 kDa, respectively. ► CSPS exhibited high antioxidant activities in vitro. ► CSPS exhibited a significant protective effect against CCl4-induced acute hepatotoxicity in mice.