Inclusion complex of GA-13315 with cyclodextrins: Preparation, characterization, inclusion mode and properties

► GA-13315 complexes with β-CD and HPβCD were prepared and characterized. ► By complexation with cyclodextrins, the water solubility of GA-13315 was improved. ► By complexation with cyclodextrins, the stability of GA-13315 was improved. ► The complexes still maintain good antitumor activities in vivo.