Optimization of extraction, preliminary characterization and hepatoprotective effects of polysaccharides from Stachys floridana Schuttl. ex Benth

► Optimal extraction conditions for polysaccharides from Stachys flordana Schuttl. ex Benth (SFPS) were obtained. ► SFPS was composed of Rha, Ara, Glc and Gal in a molar percent of 2.05, 9.16, 28.66 and 60.14, respectively. ► Administration of SFPS had a significant protective effect against CCl4-induced acute hepatotoxicity in mice.