Thermo-sensitive alginate-based injectable hydrogel for tissue engineering

► A thermo-sensitive comb-like polymer with alginate as the backbone and PNIPAAm as pendant group. ► Thermo-sensitive injectable hydrogel with LCST around 35 °C. ► Degradation can be controlled by PNIPAAm modification. ► The entrapped cells in hydrogel preserves good viability and proliferate well.