A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-κB pathway

► We demonstrated that S-GFB had lower toxicity and high selectivity. ► We proved that S-GFB prevented the entering nucleus of NF-κB p65 through notch1. ► The underlying intracellular signal of S-GFB induced apoptosis was clarified firstly.