کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10603613 | 982484 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A water-soluble inclusion complex of hypericin (HY) with β-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by 1H NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of β-cyclodextrin (β-CD) unit in CDP to HY was determined as 2:1. At 25 °C, the dissociated constant of HY-CDP was measured as 1.47 Ã 10â7 mol Lâ1 by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the β-CD drawbacks - such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 95, Issue 1, 5 June 2013, Pages 366-370
Journal: Carbohydrate Polymers - Volume 95, Issue 1, 5 June 2013, Pages 366-370
نویسندگان
Wang Zhang, Xiangdong Gong, Yin Cai, Chuanli Zhang, Xing Yu, Jian Fan, Guowang Diao,