Chitosan(PEO)/silica hybrid nanofibers as a potential biomaterial for bone regeneration

► Chitosan(PEO)/silica hybrid nanofibers were prepared by a stable sol-gel solution. ► The nanofibers presented a self-assembled core-shell structure. ► As-spun fibers were proved cytocompatible in bone-forming 7F2-cells and bioactive. ► The combined nanofibrous materials offer potential application in bone repair.