Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment

► Doxorubicin loaded acetylated fucoidan (AcFu) nanoparticles were investigated for immunochemotherapy in cancer treatment. ► The nanoparticles exhibited first-order drug release behavior for 5 days. ► AcFu treated Raw264.7 macrophages overexpressed various anti-tumor cytokines. ► The nanoparticles resist to multidrug resistance characteristics of cancer cells. ► The nanoparticles have a promising potential for one-step immunochemotherapy.